Can I book at non-airport locations?

Yes. To find a non-airport location you can search by city or by entering a U.S. street address.  The Car Details page will list the rental place's address and distance from your entered location.

Rental cars booked through Hotwire may be picked up and dropped off at different rental locations. You can even pick up at the airport and drop off the car at another location. Once you book your rental car, your drop-off location cannot be changed.